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Article

The careful control of Polo kinase by APC/C-Ube2C ensures the intercellular transport of germline centrosomes during Drosophila oogenesis.

Open biology - 1 Jun 2021

Braun Alexis Leah, Meghini Francesco, Villa-Fombuena Gema, Guermont Morgane, Fernandez-Martinez Elisa, Qian Zhang, Dolores Martín-Bermudo Maria, González-Reyes Acaimo, Glover David Moore, Kimata Yuu

Abstract excerpt

A feature of metazoan reproduction is the elimination of maternal centrosomes from the oocyte. In animals that form syncytial cysts during oogenesis, including Drosophila and human, all centrosomes within the cyst migrate to the oocyte where they are subsequently degenerated. The importance and the underlying mechanism of this event remain unclear. Here, we show that, during early Drosophila oogenesis, control of...

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PMID: 34186008
DOI: 10.1098/rsob.200371
PMCID: PMC8241486

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