Article
Inflammation But Not Biliary Obstruction Is Associated With Carbohydrate Antigen 19-9 Levels in Patients With Primary Sclerosing Cholangitis.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 1 Dec 2015
Wannhoff Andreas, Rupp Christian, Friedrich Kilian, Brune Maik, Knierim Johannes, Flechtenmacher Christa, Sauer Peter, Stremmel Wolfgang, Hov Johannes R, Schirmacher Peter, Weiss Karl Heinz, Gotthardt Daniel N
Abstract excerpt
BACKGROUND & AIMS: Assays that measure the serum level of carbohydrate antigen 19-9 (CA19-9) are used to screen patients with primary sclerosing cholangitis (PSC) for malignancies. However, in patients with PSC, cholestasis, and bacterial cholangitis, the CA19-9 level can be affected by variants in the fucosyltransferases 2 and 3 genes (FUT2 and FUT3), which regulate the production of CA19-9. We investigated how...
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