Article

The role of FGF19 in the diagnosis and pathophysiology of primary bile acid diarrhoea

2016-01-01

Abstract excerpt

Introduction: PBAD is a common cause of watery diarrhoea. It is diagnosed by the SeHCAT test and is characterized biochemically by elevated bile acid biosynthesis and low fasting FGF19. FGF19 is a gut hormone produced in the terminal ileum which negatively feeds back on hepatic BA synthesis. Aims: To assess the role of FGF19 in the pathogenesis of PBAD through characterization of fasting and postprandial FGF19 lev...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 146fc104-f2a0-5a0d-8c05-b1629968a488
DOI: 10.25560/30777

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The role of FGF19 in the diagnosis and pathophysiology of primary bile acid diarrhoeaDOI 10.25560/30777Read

Mechanisms of idiopathic bile acid malabsorption and diarrhoeaSemantic proximity Read

Investigating Fibroblast Growth Factor 19 expression in primary and secondary bile acid diarrhoeaSemantic proximity Read

Irritable bowel syndrome-diarrhea: characterization of genotype by exome sequencing, and phenotypes of bile acid synthesis and colonic transit.Semantic proximity Read

Clinical correlation with metabolic changes post cholecystectomySemantic proximity Read

Effects of NGM282, an FGF19 variant, on colonic transit and bowel function in functional constipation: a randomized phase 2 trial.Semantic proximity Read

Cholestasis and cholestatic syndromes.Semantic proximity Read

Exploring possible mechanisms for primary bile acid malabsorption: evidence for different regulation of ileal bile acid transporter transcripts in chronic diarrhoea.Semantic proximity Read

Nuclear receptor FXR, bile acids and liver damage: Introducing the progressive familial intrahepatic cholestasis with FXR mutations.Semantic proximity Read

Microbially-conjugated Bile Salts Found in Human Bile Activate the Bile Salt Receptors TGR5 and FXRSemantic proximity Read

Chenodeoxycholate in females with irritable bowel syndrome-constipation: a pharmacodynamic and pharmacogenetic analysis.Semantic proximity Read

The bile salt export pump (BSEP) in health and diseaseSemantic proximity Read

Common variant p.D19H of the hepatobiliary sterol transporter ABCG8 increases the risk of gallstones in children.Semantic proximity Read