Intracranial aneurysm risk locus 5q23.2 is associated with elevated systolic blood pressure.

doi:10.1371/journal.pgen.1002563

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Article

Intracranial aneurysm risk locus 5q23.2 is associated with elevated systolic blood pressure.

PLoS genetics - 1 Jan 2012

Gaál Emília Ilona, Salo Perttu, Kristiansson Kati, Rehnström Karola, Kettunen Johannes, Sarin Antti-Pekka, Niemelä Mika, Jula Antti, Raitakari Olli T, Lehtimäki Terho, Eriksson Johan G, Widen Elisabeth, Günel Murat, Kurki Mitja, von und Zu Fraunberg Mikael, Jääskeläinen Juha E, Hernesniemi Juha, Järvelin Marjo-Riitta, Pouta Anneli, Newton-Cheh Christopher, Salomaa Veikko, Palotie Aarno, Perola Markus

Abstract excerpt

Although genome-wide association studies (GWAS) have identified hundreds of complex trait loci, the pathomechanisms of most remain elusive. Studying the genetics of risk factors predisposing to disease is an attractive approach to identify targets for functional studies. Intracranial aneurysms (IA) are rupture-prone pouches at cerebral artery branching sites. IA is a complex disease for which GWAS have identified...

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PMID: 22438818
DOI: 10.1371/journal.pgen.1002563
PMCID: PMC3305343

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