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Article

The Pathogenicity of Anti-β2GP1-IgG Autoantibodies Depends on Fc Glycosylation

1 Jan 2015

Abstract excerpt

To analyze the glycosylation of anti-β2GP1, we investigated purified IgG from healthy children, patients with APS, and asymptomatic adult carriers of antiphospholipid antibodies. We observed that in the sera of healthy children and of patients with APS, IgG3 and IgG2 were predominant, respectively. The potentially protective anti-β2GP1-IgM was lower in the sera of healthy children. Although anti-β2GP1-associated...

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PMID: 26185769
DOI: 10.1155/2015/638129

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