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Article

Human Plasma IgG N-Glycome Profiles Reveal a Proinflammatory Phenotype in Chronic Thromboembolic Pulmonary Hypertension.

Hypertension (Dallas, Tex. : 1979) - 1 Sept 2023

Zhang Ze-Jian, Wang Hui-Fang, Lian Tian-Yu, Zhou Yu-Ping, Xu Xi-Qi, Guo Fan, Wei Yun-Peng, Li Jing-Yi, Sun Kai, Liu Chao, Pan Lu-Rong, Ren Ming, Nie Lei, Dai Hai-Long, Jing Zhi-Cheng

Abstract excerpt

BACKGROUND: The pathological mechanism of chronic thromboembolic pulmonary hypertension (CTEPH) is not fully understood, and inflammation has been reported to be one of its etiological factors. IgG regulates systemic inflammatory homeostasis, primarily through its N-glycans. Little is known about IgG N-glycosylation in CTEPH. We aimed to map the IgG N-glycome of CTEPH to provide new insights into its pathogenesis...

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Identifiers

PMID: 37449418
DOI: 10.1161/HYPERTENSIONAHA.123.21408

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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