Article
High throughput isolation and glycosylation analysis of IgG-variability and heritability of the IgG glycome in three isolated human populations.
Molecular & cellular proteomics : MCP - 1 Oct 2011
Pucić Maja, Knezević Ana, Vidic Jana, Adamczyk Barbara, Novokmet Mislav, Polasek Ozren, Gornik Olga, Supraha-Goreta Sandra, Wormald Mark R, Redzić Irma, Campbell Harry, Wright Alan, Hastie Nicholas D, Wilson James F, Rudan Igor, Wuhrer Manfred, Rudd Pauline M, Josić Djuro, Lauc Gordan
Abstract excerpt
All immunoglobulin G molecules carry N-glycans, which modulate their biological activity. Changes in N-glycosylation of IgG associate with various diseases and affect the activity of therapeutic antibodies and intravenous immunoglobulins. We have developed a novel 96-well protein G monolithic plate and used it to rapidly isolate IgG from plasma of 2298 individuals from three isolated human populations. N-glycans...
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