Spectrum and frequencies of BRCA1/2 mutations in Bulgarian high risk breast cancer patients.

doi:10.1186/s12885-015-1516-2

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Spectrum and frequencies of BRCA1/2 mutations in Bulgarian high risk breast cancer patients.

BMC cancer - 17 Jul 2015

Dodova Rumyana Ivanova, Mitkova Atanaska Velichkova, Dacheva Daniela Rosenova, Hadjo Lina Basam, Vlahova Alexandrina Ivanova, -Hadjieva Margarita Stoyanova Taushanova, Valev Spartak Stoyanov, Caulevska Marija Mitko, Popova Stanislava Dimitrova, Popov Ivan Emilov, Dikov Tihomir Iliichev, Sedloev Theophil Angelov, Ionkov Atanas Stefanov, Timcheva Konstanta Velinova, Christova Svetlana Liubomirova, Kremensky Ivo Marinov, Mitev Vanio Ivanov, Kaneva Radka Petrova

Abstract excerpt

BACKGROUND: About 3885 women are diagnosed with breast cancer and 1285 die from the disease each year in Bulgaria. However no genetic testing to identify the mutations in high-risk families has been provided so far. METHODS: We evaluated 200 Bulgarian women with primary invasive breast cancer and with personal/ family history of breast cancer for the presence of unequivocally damaging germline mutations in...

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PMID: 26183948
DOI: 10.1186/s12885-015-1516-2
PMCID: PMC4504066

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BRCA1
BRCA2

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