Article
Founder vs. non-founder BRCA1/2 pathogenic alleles: the analysis of Belarusian breast and ovarian cancer patients and review of other studies on ethnically homogenous populations.
Familial cancer - 1 Jan 2023
Yanus G A, Savonevich E L, Sokolenko A P, Romanko A A, Ni V I, Bakaeva E Kh, Gorustovich O A, Bizin I V, Imyanitov E N
Abstract excerpt
The spectrum of BRCA1/2 mutations demonstrates significant interethnic variations. We analyzed for the first time the entire BRCA1/2 coding region in 340 Belarusian cancer patients with clinical signs of BRCA1/2-related disease, including 168 women with bilateral and/or early-onset breast cancer (BC), 104 patients with ovarian cancer and 68 subjects with multiple primary malignancies involving BC and/or OC....
Topics
- Female
- Humans
- Alleles
- BRCA1 Protein
- BRCA2 Protein
- Breast Neoplasms
- Founder Effect
- Genetic Predisposition to Disease
- Mutation
- Ovarian Neoplasms