Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Spectrum and characterisation of BRCA1 and BRCA2 deleterious mutations in high-risk Czech patients with breast and/or ovarian cancer.

BMC cancer - 20 May 2008

Machackova Eva, Foretova Lenka, Lukesova Mirka, Vasickova Petra, Navratilova Marie, Coene Ilse, Pavlu Hana, Kosinova Veronika, Kuklova Jitka, Claes Kathleen

Abstract excerpt

BACKGROUND: The incidence of breast cancer has doubled over the past 20 years in the Czech Republic. Hereditary factors may be a cause of young onset, bilateral breast or ovarian cancer, and familial accumulation of the disease. BRCA1 and BRCA2 mutations account for an important fraction of hereditary breast and ovarian cancer cases. One thousand and ten unrelated high-risk probands with breast and/or ovarian...

Topics

Age of Onset
BRCA1 Protein
BRCA2 Protein
Breast Neoplasms
Breast Neoplasms, Male
Czech Republic
DNA Mutational Analysis
Female
Genetic Predisposition to Disease
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mutation

Ovarian Neoplasms

Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 18489799
DOI: 10.1186/1471-2407-8-140
PMCID: PMC2413254

Genes

BRCA1
BRCA2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Spectrum and characterisation of BRCA1 and BRCA2 deleterious mutations in high-risk Czech patients with breast and/or ovarian cancer.PMID 18489799Read ↗

High proportion of recurrent germline mutations in the BRCA1 gene in breast and ovarian cancer patients from the Prague areaSemantic proximity Read ↗

BRCA1 and BRCA2 mutations in women with familial or early-onset breast/ovarian cancer in the Czech Republic.Semantic proximity Read ↗

Spectrum of genetic variants of BRCA1 and BRCA2 in a German single center study.Semantic proximity Read ↗

Novel BRCA1 and BRCA2 pathogenic mutations in Slovene hereditary breast and ovarian cancer families.Semantic proximity Read ↗

High occurrence of BRCA1 intragenic rearrangements in hereditary breast and ovarian cancer syndrome in the Czech RepublicSemantic proximity Read ↗

Comprehensive analysis of 989 patients with breast or ovarian cancer provides BRCA1 and BRCA2 mutation profiles and frequencies for the German population.Semantic proximity Read ↗

The spectrum and incidence of BRCA1 pathogenic mutations in Slovak breast/ovarian cancer families.Semantic proximity Read ↗

Frequency of mutations in BRCA genes and other candidate genes in high-risk probands or probands with breast or ovarian cancer in the Czech Republic.Semantic proximity Read ↗

BRCA1/2 mutations in Swiss patients with familial or early-onset breast and ovarian cancer.Semantic proximity Read ↗

Frequency and spectrum of founder and non-founder BRCA1 and BRCA2 mutations in a large series of Russian breast cancer and ovarian cancer patients.Semantic proximity Read ↗

Five recurrent BRCA1/2 mutations are responsible for cancer predisposition in the majority of Slovenian breast cancer families.Semantic proximity Read ↗

Frequency of BRCA1 and BRCA2 causative founder variants in ovarian cancer patients in South-East PolandSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.