Article
The Association and Risk Prediction of the Ubiquitination Pathway Genetic Variants and Lung Cancer Incidence: A Nested Case-Control Study.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 3 Aug 2026
Mao Jianing, Leng Lingyun, Zhu Tianyi, Wang Jiayi, Zhao Genming, Liu Xing, Liu Hongliang, Wu Yiling, Cheng Lei, Zhang Ruoxin
Abstract excerpt
BACKGROUND: Dysregulation of the ubiquitin-proteasome system (UPS) promotes tumorigenesis, but population-level evidence linking UPS variants to lung cancer risk is limited. METHODS: We conducted a two-stage genetic association study. In the discovery stage, using a nested case-control design, 70,801 SNPs from 750 UPS-related genes were analyzed in 612 lung cancer cases and 901 controls from the Shanghai Suburban...
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