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Article

Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress.

Neuron - 15 Jul 2015

Pickrell Alicia M, Huang Chiu-Hui, Kennedy Scott R, Ordureau Alban, Sideris Dionisia P, Hoekstra Jake G, Harper J Wade, Youle Richard J

Abstract excerpt

Parkinson's disease (PD) is a neurodegenerative disease caused by the loss of dopaminergic neurons in the substantia nigra. PARK2 mutations cause early-onset forms of PD. PARK2 encodes an E3 ubiquitin ligase, Parkin, that can selectively translocate to dysfunctional mitochondria to promote their removal by autophagy. However, Parkin knockout (KO) mice do not display signs of neurodegeneration. To assess Parkin...

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Identifiers

PMID: 26182419
DOI: 10.1016/j.neuron.2015.06.034
PMCID: PMC4803114

Genes

PINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress.PMID 26182419Read ↗

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