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Article

Parkin deficiency accelerates consequences of mitochondrial DNA deletions and Parkinsonism.

Neurobiology of disease - 1 Apr 2017

Song Lanying, McMackin Marissa, Nguyen Andy, Cortopassi Gino

Abstract excerpt

Parkinson's disease (PD) is a neurodegenerative condition caused by age-related death of dopaminergic (DA) neurons in the substantia nigra (SN). Mitochondrial DNA (mtDNA) deletions rise exponentially with age in humans and reach their highest levels approaching 60% in dopaminergic neurons of the substantia nigra and overlap with dying neurons. Parkin deletion causes Parkinsonism in humans, presumably through a...

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Identifiers

PMID: 28042097
DOI: 10.1016/j.nbd.2016.12.024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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