Genomic Correlate of Exceptional Erlotinib Response in Head and Neck Squamous Cell Carcinoma.

doi:10.1001/jamaoncol.2015.34

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Article

Genomic Correlate of Exceptional Erlotinib Response in Head and Neck Squamous Cell Carcinoma.

JAMA oncology - 1 May 2015

Van Allen Eliezer M, Lui Vivian W Y, Egloff Ann Marie, Goetz Eva M, Li Hua, Johnson Jonas T, Duvvuri Umamaheswar, Bauman Julie E, Stransky Nicolas, Zeng Yan, Gilbert Breean R, Pendleton Kelsey P, Wang Lin, Chiosea Simion, Sougnez Carrie, Wagle Nikhil, Zhang Fan, Du Yu, Close David, Johnston Paul A, McKenna Aaron, Carter Scott L, Golub Todd R, Getz Gad, Mills Gordon B, Garraway Levi A, Grandis Jennifer R

Abstract excerpt

IMPORTANCE: Randomized clinical trials demonstrate no benefit for epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors in unselected patients with head and neck squamous cell carcinoma (HNSCC). However, a patient with stage IVA HNSCC received 13 days of neoadjuvant erlotinib and experienced a near-complete histologic response. OBJECTIVE: To determine a mechanism of exceptional response to erlotinib...

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Identifiers

PMID: 26181029
DOI: 10.1001/jamaoncol.2015.34
PMCID: PMC4557203

Genes

EGFR
MAPK1

Variants

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