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Article

Whole exome sequencing uncovers HRAS mutations as potential mediators of resistance to metronomic chemotherapy.

Gene - 30 Jan 2024

Sambath Janani, Noronha Vanita, Manda Srikanth S, Mishra Rohit, Chandrani Pratik, Patil Vijay, Menon Nandini, Chougule Anuradha, Ramachandran Venkatraman, Limaye Sewanti, Kuriakose Moni A, Banavali Shripad D, Kumar Prashant, Prabhash Kumar

Abstract excerpt

OBJECTIVES: The aim of this pilot study is to identify the genetic factors that contribute to the response of metronomic chemotherapy in head and neck squamous cell carcinoma (HNSCC) patients using whole-exome sequencing (WES). This study would facilitate the identification of predictive biomarkers, which would enable personalized treatment strategies and improve treatment outcomes for patients with HNSCC....

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Share to Carcinoma, Squamous Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37918550
DOI: 10.1016/j.gene.2023.147952

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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