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Blimp‐1 homolog Hobit identifies effector‐type lymphocytes in humans

15 Jul 2015

Abstract excerpt

Human cytomegalovirus (CMV) induces the formation of effector CD8(+) T cells that are maintained for decades during the latent stage of infection. Effector CD8(+) T cells appear quiescent, but maintain constitutive cytolytic capacity and can immediately produce inflammatory cytokines such as IFN-γ after stimulation. It is unclear how effector CD8(+) T cells can be constitutively maintained in a terminal stage of...

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PMID: 26179882
DOI: 10.1002/eji.201545650

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