Article
Helper T cell diversity and plasticity.
Current opinion in immunology - 1 Jun 2012
Nakayamada Shingo, Takahashi Hayato, Kanno Yuka, O'Shea John J
Abstract excerpt
CD4(+) helper T cells play crucial roles for host defense and immune-mediated disease by their ability to differentiate into specialized subsets. These subsets attain restricted patterns of cytokine secretion and specific expression of master transcription factors in response to microbial pathogens. Classically, the various helper CD4(+) T cell subsets have been viewed as terminally differentiated lineages with...
Topics
- Animals
- Cell Differentiation
- Gene Expression Regulation
- Humans
- MicroRNAs
- Phenotype
- T-Lymphocytes, Helper-Inducer