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Article

Hobit and Blimp-1 instruct the differentiation of iNKT cells into resident-phenotype lymphocytes after lineage commitment.

European journal of immunology - 1 Mar 2022

Kragten Natasja Am, Taggenbrock Renske Lre, Parga Vidal Loreto, van Lier Rene Aw, Stark Regina, van Gisbergen Klaas Pjm

Abstract excerpt

iNKT cells are CD1d-restricted T cells that play a pro-inflammatory or regulatory role in infectious and autoimmune diseases. Thymic precursors of iNKT cells eventually develop into distinct iNKT1, iNKT2, and iNKT17 lineages in the periphery. It remains unclear whether iNKT cells retain developmental potential after lineage commitment. iNKT cells acquire a similar phenotype as tissue-resident memory T cells,...

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PMID: 34897659
DOI: 10.1002/eji.202149360
PMCID: PMC9305946

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