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Article

miR-135b- and miR-146b-dependent silencing of calcium-sensing receptor expression in colorectal tumors

14 Jul 2015

Abstract excerpt

Studies have shown that the calcium-sensing receptor (CaSR) mediates the antitumorigenic effects of calcium against colorectal cancer (CRC). Expression of the CaSR in colorectal tumors is often reduced. We have reported previously that silencing of CaSR in CRC is caused in part by methylation of CaSR promoter 2 and loss of histone acetylation. We investigated the impact of aberrant microRNA expression on loss of...

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PMID: 26178670
DOI: 10.1002/ijc.29681

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