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Article

Inhibition of Bcl-xL sensitizes cells to mitotic blockers, but not mitotic drivers

1 Aug 2016

Abstract excerpt

Cell fate in response to an aberrant mitosis is governed by two competing networks: the spindle assembly checkpoint (SAC) and the intrinsic apoptosis pathway. The mechanistic interplay between these two networks is obscured by functional redundancy and the ability of cells to die either in mitosis or in the subsequent interphase. By coupling time-lapse microscopy with selective pharmacological agents, we...

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PMID: 27512141
DOI: 10.1098/rsob.160134

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