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Article

Bcl-xL controls a switch between cell death modes during mitotic arrest

12 Jun 2014

Abstract excerpt

Antimitotic agents such as microtubule inhibitors (paclitaxel) are widely used in cancer therapy while new agents blocking mitosis onset are currently in development. All these agents impose a prolonged mitotic arrest in cancer cells that relies on sustained activation of the spindle assembly checkpoint and may lead to subsequent cell death by incompletely understood molecular events. We have investigated the...

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PMID: 24922075
DOI: 10.1038/cddis.2014.251

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