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Intravital FRET Imaging of Tumor Cell Viability and Mitosis during Chemotherapy

15 May 2013

Abstract excerpt

Taxanes, such as docetaxel, are microtubule-targeting chemotherapeutics that have been successfully used in the treatment of cancer. Based on data obtained from cell cultures, it is believed that taxanes induce tumor cell death by specifically perturbing mitotic progression. Here, we report on data that suggest that this generally accepted view may be too simplified. We describe a high-resolution intravital...

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PMID: 23691140
DOI: 10.1371/journal.pone.0064029

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