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TNBC response to paclitaxel phenocopies interferon response which reveals cell cycle-associated resistance mechanisms

2024-06-06

Abstract excerpt

<h4>ABSTRACT</h4> Paclitaxel is a standard of care neoadjuvant therapy for patients with triple negative breast cancer (TNBC); however, it shows limited benefit for locally advanced or metastatic disease. Here we used a coordinated experimental-computational approach to explore the influence of paclitaxel on the cellular and molecular responses of TNBC cells. We found that escalating doses of paclitaxel resulted...

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Literature Corpus work
b8baefc3-f3b7-5896-905e-9e142f26322f
DOI
10.1101/2024.06.04.596911
Open publication

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TNBC response to paclitaxel phenocopies interferon response which reveals cell cycle-associated resistance mechanismsDOI 10.1101/2024.06.04.596911
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