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Article

The second C2-domain of copine-2, copine-6 and copine-7 is responsible for their calcium-dependent membrane association.

The FEBS journal - 1 Oct 2015

Perestenko Pavel, Watanabe Masanori, Beusnard-Bee Tobias, Guna Prakash, McIlhinney Jeffrey

Abstract excerpt

The copine family of proteins contains nine members with a similar domain structure, namely two N-terminal C2-domains (C2A and C2B) and a C-terminal A-domain. The former are thought to be responsible for binding to the inner face of the plasma membrane following increases in intracellular calcium levels, whereas the A-domain has been suggested to be a protein-binding structure. In this study, we examined the...

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PMID: 26175110
DOI: 10.1111/febs.13370

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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