A ten-residue domain (Y11-A20) in the NH2-terminus modulates membrane association of annexin A7.

doi:10.1016/j.bbalip.2006.05.018

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Article

A ten-residue domain (Y11-A20) in the NH2-terminus modulates membrane association of annexin A7.

Biochimica et biophysica acta - 1 Jul 2006

Chander Avinash, Naidu Devendra G, Chen Xiao-Liang

Abstract excerpt

Annexin A7 (synexin, annexin VII) is postulated to promote membrane fusion during surfactant secretion in alveolar type II cells and catecholamine secretion in adrenal chromaffin cells. Recently, we demonstrated that the 1-29 residues in the NH(2)-terminus could, possibly by interaction with the COOH-terminus, influence the Ca(2+)-dependent membrane binding, aggregation, and fusion properties of annexin A7 (A7)....

Topics

Animals
Annexin A7
Binding Sites
Cell Membrane
Membrane Fusion
Mutation
Protein Binding
Protein Folding
Protein Structure, Tertiary
Rats
Recombinant Proteins
Structure-Activity Relationship

Source

Open in PubMed

Identifiers

PMID: 16843057
DOI: 10.1016/j.bbalip.2006.05.018

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