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Article

Hypoxia-inducible factor 3-alpha expression is associated with the stable chondrocyte phenotype.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Nov 2015

Markway Brandon D, Cho Holly, Zilberman-Rudenko Jevgenia, Holden Paul, McAlinden Audrey, Johnstone Brian

Abstract excerpt

The hypoxia-inducible factors HIF-1α and HIF-2α are important regulators of the chondrocyte phenotype but little is known about HIF-3α in cartilage. The objective of this study was to characterize HIF-3α (HIF3A) expression during chondrocyte differentiation in vitro and in native cartilage tissues. HIF3A, COL10A1, and MMP13 were quantified in mesenchymal stem cells (MSCs) and articular chondrocytes from healthy...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26174816
DOI: 10.1002/jor.22930

Genes

MMP13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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