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Article

Combined 3D and hypoxic culture improves cartilage-specific gene expression in human chondrocytes

24 Mar 2011

Abstract excerpt

BACKGROUND AND PURPOSE: In vitro expansion of autologous chondrocytes is an essential part of many clinically used cartilage repair treatments. Native chondrocytes reside in a 3-dimensional (3D) network and are exposed to low levels of oxygen. We compared monolayer culture to combined 3D and hypoxic culture using quantitative gene expression analysis. METHODS: Cartilage biopsies were collected from the...

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PMID: 21434761
DOI: 10.3109/17453674.2011.566135

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