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Article

Amplification of Glyceronephosphate O-Acyltransferase and Recruitment of USP30 Stabilize DRP1 to Promote Hepatocarcinogenesis.

Cancer research - 15 Oct 2018

Gu Li, Zhu Yahui, Lin Xi, Li Yajun, Cui Kaisa, Prochownik Edward V, Li Youjun

Abstract excerpt

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide, and the underlying pathophysiology of HCC is highly complex. In this study, we report that, in a bioinformatic screen of 2,783 genes encoding metabolic enzymes, GNPAT, which encodes the enzyme glyceronephosphate O-acyltransferase, is amplified, upregulated, and highly correlated with poor clinical outcome in human patients with...

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Identifiers

PMID: 30143522
DOI: 10.1158/0008-5472.CAN-18-0340

Genes

GNPAT
USP30

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