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Article

eIF3 controls cell size independently of S6K1-activity.

Oncotarget - 15 Sept 2015

Schipany Katharina, Rosner Margit, Ionce Loredana, Hengstschläger Markus, Kovacic Boris

Abstract excerpt

All multicellular organisms require a life-long regulation of the number and the size of cells, which build up their organs. mTOR acts as a signaling nodule for the regulation of protein synthesis and growth. To activate the translational cascade, mTOR phosphorylates S6 kinase (S6K1), which is liberated from the eIF3-complex and mobilized for activation of its downstream targets. How S6K1 regulates cell size...

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Identifiers

PMID: 26172298
DOI: 10.18632/oncotarget.4458
PMCID: PMC4695191

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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