Article
Foxo1 Is a T Cell-Intrinsic Inhibitor of the RORγt-Th17 Program.
Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2015
Lainé Alexandra, Martin Bruno, Luka Marine, Mir Lucile, Auffray Cédric, Lucas Bruno, Bismuth Georges, Charvet Céline
Abstract excerpt
An uncontrolled exaggerated Th17 response can drive the onset of autoimmune and inflammatory diseases. In this study, we show that, in T cells, Foxo1 is a negative regulator of the Th17 program. Using mixed bone marrow chimeras and Foxo1-deficient mice, we demonstrate that this control is effective in vivo, as well as in vitro during differentiation assays of naive T cells with specific inhibitor of Foxo1 or...
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