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Article

T cells require Foxo1 to populate the peripheral lymphoid organs.

European journal of immunology - 1 Nov 2009

Gubbels Bupp Melanie R, Edwards Bonnie, Guo Caiying, Wei Datsen, Chen Gang, Wong Brian, Masteller Emma, Peng Stanford L

Abstract excerpt

Forkhead transcription factors play critical roles in leukocyte homeostasis. To study further the immunological functions of Foxo1, we generated mice that selectively lack Foxo1 in T cells (Foxo1(flox/flox) Lck.cre(+)conditional knockout mice (cKO)). Although thymocyte development appeared relatively normal, Foxo1 cKO mice harbored significantly increased percentages of mature single positive T cells in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19658095
DOI: 10.1002/eji.200939427
PMCID: PMC3010613

Genes

CCR7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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