The emerging role of TRPV4 in skeletal biology: Mechanotransduction, mutation, and therapeutic potential.

doi:10.1016/j.ceca.2026.103108

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Article

The emerging role of TRPV4 in skeletal biology: Mechanotransduction, mutation, and therapeutic potential.

Cell calcium - 1 Mar 2026

Lyu Bowen, Lin Jiachen, Chen Lunhao, Wang Yue

Abstract excerpt

The transient receptor potential vanilloid 4 (TRPV4) ion channel is a pivotal regulator of calcium homeostasis, with its pleiotropic functions being increasingly elucidated across diverse physiological systems. Emerging evidence now underscores its indispensable role within the skeletal system, where it transduces multifaceted stimuli-notably mechanical loading and osmotic stress-into precise calcium signals that...

Topics

TRPV Cation Channels
Humans
Mechanotransduction, Cellular
Animals
Mutation
Bone and Bones
Chondrocytes

Source

Open in PubMed

Identifiers

PMID: 41529958
DOI: 10.1016/j.ceca.2026.103108

Genes

TRPV4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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