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Article

Non-Invasive Intravital Imaging of siRNA-Mediated Mutant Keratin Gene Repression in Skin.

Molecular imaging and biology - 1 Feb 2016

Hickerson Robyn P, Speaker Tycho J, Lara Maria Fernanda, González-González Emilio, Flores Manuel A, Contag Christopher H, Kaspar Roger L

Abstract excerpt

PURPOSE: Small interfering RNAs (siRNAs) specifically and potently inhibit target gene expression. Pachyonychia congenita (PC) is a skin disorder caused by mutations in genes encoding keratin (K) 6a/b, K16, and K17, resulting in faulty intermediate filaments. A siRNA targeting a single nucleotide, PC-relevant mutation inhibits K6a expression and has been evaluated in the clinic with encouraging results....

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Source

Identifiers

PMID: 26169581
DOI: 10.1007/s11307-015-0875-z

Genes

PC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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