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Article

A Novel Fluorescence-Based Screen of Gene Editing Molecules for Junctional Epidermolysis Bullosa.

International journal of molecular sciences - 8 Mar 2023

Zwicklhuber Janine, Kocher Thomas, Liemberger Bernadette, Hainzl Stefan, Bischof Johannes, Strunk Dirk, Raninger Anna M, Gratz Iris, Wally Verena, Guttmann-Gruber Christina, Hofbauer Josefina Piñón, Bauer Johann W, Koller Ulrich

Abstract excerpt

Junctional epidermolysis bullosa (JEB) is a severe blistering skin disease caused by mutations in genes encoding structural proteins essential for skin integrity. In this study, we developed a cell line suitable for gene expression studies of the JEB-associated COL17A1 encoding type XVII collagen (C17), a transmembrane protein involved in connecting basal keratinocytes to the underlying dermis of the skin. Using...

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Identifiers

PMID: 36982270
DOI: 10.3390/ijms24065197
PMCID: PMC10049061

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