Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mouse models in preclinical studies for pachyonychia congenita.

The journal of investigative dermatology. Symposium proceedings - 1 Oct 2005

Chen Jiang, Roop Dennis R

Abstract excerpt

The similarities between the human and mouse genomes often allow researchers to make accurate predictions about the roles of their human counterparts. Because of the similar physiology between these two mammals, mice are used extensively in the laboratory to investigate the mechanisms of human diseases. Furthermore, mice provide us with the option of testing the toxicity of drugs and the safety of therapeutic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Darier Disease
Share to Ectodermal Dysplasia
Share to Genetic Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Keratins

Share to Keratoderma, Palmoplantar

Share to Mice, Mutant Strains

Share to Mice, Transgenic

Share to Nails, Malformed

Source

Identifiers

PMID: 16250208
DOI: 10.1111/j.1087-0024.2005.10206.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mouse models in preclinical studies for pachyonychia congenita.PMID 16250208Read ↗

Overcoming functional redundancy to elicit pachyonychia congenita-like nail lesions in transgenic mice.Semantic proximity Read ↗

Development of skin-humanized mouse models of pachyonychia congenita.Semantic proximity Read ↗

The phenotypic and molecular genetic features of pachyonychia congenita.Semantic proximity Read ↗

Insights into genotype-phenotype correlation in pachyonychia congenita from the human intermediate filament mutation database.Semantic proximity Read ↗

Keratin 16-null mice develop palmoplantar keratoderma, a hallmark feature of pachyonychia congenita and related disorders.Semantic proximity Read ↗

Revisiting pachyonychia congenita: a case-cohort study of 815 patients.Semantic proximity Read ↗

Pachyonychia congenita in pediatric patients: natural history, features, and impact.Semantic proximity Read ↗

Clinical and pathological features of pachyonychia congenita.Semantic proximity Read ↗

Pachyonychia congenita cornered: report on the 11th Annual International Pachyonychia Congenita Consortium Meeting.Semantic proximity Read ↗

The genetic basis of pachyonychia congenita.Semantic proximity Read ↗

A large mutational study in pachyonychia congenita.Semantic proximity Read ↗

Pachyonychia congenita patients with mutations in KRT6A have more extensive disease compared with patients who have mutations in KRT16.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.