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Article

Rapid genotype imputation from sequence with reference panels.

Nature genetics - 1 Jul 2021

Davies Robert W, Kucka Marek, Su Dingwen, Shi Sinan, Flanagan Maeve, Cunniff Christopher M, Chan Yingguang Frank, Myers Simon

Abstract excerpt

Inexpensive genotyping methods are essential to modern genomics. Here we present QUILT, which performs diploid genotype imputation using low-coverage whole-genome sequence data. QUILT employs Gibbs sampling to partition reads into maternal and paternal sets, facilitating rapid haploid imputation using large reference panels. We show this partitioning to be accurate over many megabases, enabling highly accurate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotyping Techniques

Share to Polymorphism, Single Nucleotide

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Share to Sequence Analysis, DNA

Share to Whole Genome Sequencing

Source

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Identifiers

PMID: 34083788
DOI: 10.1038/s41588-021-00877-0
PMCID: PMC7611184

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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