Article
Basal core promoter mutations of hepatitis B virus increase the risk of hepatocellular carcinoma in hepatitis B carriers.
Gastroenterology - 1 Feb 2003
Kao Jia-Horng, Chen Pei-Jer, Lai Ming-Yang, Chen Ding-Shinn
Abstract excerpt
BACKGROUND & AIMS: Hepatitis B viral (HBV) genotype C is associated with the development of hepatocellular carcinoma (HCC) compared with genotype B; however, the virologic factors contributing to the pathogenic differences remain unknown. We investigated the prevalence of T1762/A1764 basal core promoter mutant in a cohort of 250 genotype B- or C-infected HBV carriers with different stages of liver disease to...
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