Article
Integration of multiethnic fine-mapping and genomic annotation to prioritize candidate functional SNPs at prostate cancer susceptibility regions.
Human molecular genetics - 1 Oct 2015
Han Ying, Hazelett Dennis J, Wiklund Fredrik, Schumacher Fredrick R, Stram Daniel O, Berndt Sonja I, Wang Zhaoming, Rand Kristin A, Hoover Robert N, Machiela Mitchell J, Yeager Merideth, Burdette Laurie, Chung Charles C, Hutchinson Amy, Yu Kai, Xu Jianfeng, Travis Ruth C, Key Timothy J, Siddiq Afshan, Canzian Federico, Takahashi Atsushi, Kubo Michiaki, Stanford Janet L, Kolb Suzanne, Gapstur Susan M, Diver W Ryan, Stevens Victoria L, Strom Sara S, Pettaway Curtis A, Al Olama Ali Amin, Kote-Jarai Zsofia, Eeles Rosalind A, Yeboah Edward D, Tettey Yao, Biritwum Richard B, Adjei Andrew A, Tay Evelyn, Truelove Ann, Niwa Shelley, Chokkalingam Anand P, Isaacs William B, Chen Constance, Lindstrom Sara, Le Marchand Loic, Giovannucci Edward L, Pomerantz Mark, Long Henry, Li Fugen, Ma Jing, Stampfer Meir, John Esther M, Ingles Sue A, Kittles Rick A, Murphy Adam B, Blot William J, Signorello Lisa B, Zheng Wei, Albanes Demetrius, Virtamo Jarmo, Weinstein Stephanie, Nemesure Barbara, Carpten John, Leske M Cristina, Wu Suh-Yuh, Hennis Anselm J M, Rybicki Benjamin A, Neslund-Dudas Christine, Hsing Ann W, Chu Lisa, Goodman Phyllis J, Klein Eric A, Zheng S Lilly, Witte John S, Casey Graham, Riboli Elio, Li Qiyuan, Freedman Matthew L, Hunter David J, Gronberg Henrik, Cook Michael B, Nakagawa Hidewaki, Kraft Peter, Chanock Stephen J, Easton Douglas F, Henderson Brian E, Coetzee Gerhard A, Conti David V, Haiman Christopher A
Abstract excerpt
Interpretation of biological mechanisms underlying genetic risk associations for prostate cancer is complicated by the relatively large number of risk variants (n = 100) and the thousands of surrogate SNPs in linkage disequilibrium. Here, we combined three distinct approaches: multiethnic fine-mapping, putative functional annotation (based upon epigenetic data and genome-encoded features), and expression...
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