Article
Genome-wide testing of putative functional exonic variants in relationship with breast and prostate cancer risk in a multiethnic population.
PLoS genetics - 1 Mar 2013
Haiman Christopher A, Han Ying, Feng Ye, Xia Lucy, Hsu Chris, Sheng Xin, Pooler Loreall C, Patel Yesha, Kolonel Laurence N, Carter Erin, Park Karen, Le Marchand Loic, Van Den Berg David, Henderson Brian E, Stram Daniel O
Abstract excerpt
Rare variation in protein coding sequence is poorly captured by GWAS arrays and has been hypothesized to contribute to disease heritability. Using the Illumina HumanExome SNP array, we successfully genotyped 191,032 common and rare non-synonymous, splice site, or nonsense variants in a multiethnic sample of 2,984 breast cancer cases, 4,376 prostate cancer cases, and 7,545 controls. In breast cancer, the strongest...
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