Article
Mutant IDH1 Dysregulates the Differentiation of Mesenchymal Stem Cells in Association with Gene-Specific Histone Modifications to Cartilage- and Bone-Related Genes.
PloS one - 1 Jan 2015
Jin Yonghui, Elalaf Hassan, Watanabe Makoto, Tamaki Sakura, Hineno Sho, Matsunaga Kazuhito, Woltjen Knut, Kobayashi Yukiko, Nagata Sanae, Ikeya Makoto, Kato Tomohisa, Okamoto Takeshi, Matsuda Shuichi, Toguchida Junya
Abstract excerpt
Somatic mutations in the isocitrate dehydrogenase (IDH)1/2 genes endow encoding proteins with neomorphic activity to produce the potential oncometabolite, 2-hydroxyglutarate (2-HG), which induces the hypermethylation of histones and DNA. The incidence of IDH1/2 mutations in cartilaginous tumors was previously shown to be the highest among various types of tumors, except for those in the central nervous system....
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