Article
IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours.
The Journal of pathology - 1 Jul 2011
Amary M Fernanda, Bacsi Krisztian, Maggiani Francesca, Damato Stephen, Halai Dina, Berisha Fitim, Pollock Robin, O'Donnell Paul, Grigoriadis Anita, Diss Tim, Eskandarpour Malihe, Presneau Nadège, Hogendoorn Pancras Cw, Futreal Andrew, Tirabosco Roberto, Flanagan Adrienne M
Abstract excerpt
Somatic mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 occur in gliomas and acute myeloid leukaemia (AML). Since patients with multiple enchondromas have occasionally been reported to have these conditions, we hypothesized that the same mutations would occur in cartilaginous neoplasms. Approximately 1200 mesenchymal tumours, including 220 cartilaginous tumours, 222 osteosarcomas and another ∼750 bone and...
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