Article
An Integrated Clinical Genomic and Transcriptomic Subgrouping of Central Chondrosarcoma.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Dec 2025
Meijer Debora M, Venneker Sanne, Ameline Baptiste, Erdem Zeynep, Cardoso Sara, Ruano Dina, Briaire-de Bruijn Inge H, van den Akker Brendy E, Wijers-Koster Pauline M, Scholte Claire H J, van Praag Veroniek M, van de Sande Michiel A J, Kuijjer Marieke L, Baumhoer Daniel, de Miranda Noel F C C, Bovée Judith V M G
Abstract excerpt
Central conventional chondrosarcoma, a malignant cartilage-producing bone tumor, is the second most common bone sarcoma. Chondrosarcomas are histologically graded, which is so far the best predictor of survival. Early mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 genes are frequent, leading to the production of the oncometabolite D-2-hydroxyglutarate, which affects DNA methylation, resulting in a...
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- Humans
- Chondrosarcoma
- Female
- Male
- Bone Neoplasms