Article
Induction of sarcomas by mutant IDH2.
Genes & development - 15 Sept 2013
Lu Chao, Venneti Sriram, Akalin Altuna, Fang Fang, Ward Patrick S, Dematteo Raymond G, Intlekofer Andrew M, Chen Chong, Ye Jiangbin, Hameed Meera, Nafa Khedoudja, Agaram Narasimhan P, Cross Justin R, Khanin Raya, Mason Christopher E, Healey John H, Lowe Scott W, Schwartz Gary K, Melnick Ari, Thompson Craig B
Abstract excerpt
More than 50% of patients with chondrosarcomas exhibit gain-of-function mutations in either isocitrate dehydrogenase 1 (IDH1) or IDH2. In this study, we performed genome-wide CpG methylation sequencing of chondrosarcoma biopsies and found that IDH mutations were associated with DNA hypermethylation at CpG islands but not other genomic regions. Regions of CpG island hypermethylation were enriched for genes...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.