Article
High-level of viral genomic diversity in cervical cancers: A Brazilian study on human papillomavirus type 16.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Aug 2015
de Oliveira Cristina Mendes, Bravo Ignacio G, Santiago e Souza Nathália Caroline, Genta Maria Luiza Nogueira Dias, Fregnani José Humberto Tavares Guerreiro, Tacla Maricy, Carvalho Jesus Paula, Longatto-Filho Adhemar, Levi José Eduardo
Abstract excerpt
Invasive cervical cancer (ICC) is the third most frequent cancer among women worldwide and is associated with persistent infection by carcinogenic human papillomaviruses (HPVs). The combination of large populations of viral progeny and decades of sustained infection may allow for the generation of intra-patient diversity, in spite of the assumedly low mutation rates of PVs. While the natural history of chronic...
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