Article
Genotype-guided versus standard vitamin K antagonist dosing algorithms in patients initiating anticoagulation. A systematic review and meta-analysis.
Thrombosis and haemostasis - 1 Oct 2015
Belley-Cote Emilie P, Hanif Hasib, D'Aragon Frederick, Eikelboom John W, Anderson Jeffrey L, Borgman Mark, Jonas Daniel E, Kimmel Stephen E, Manolopoulos Vangelis G, Baranova Ekaterina, Maitland-van der Zee Anke H, Pirmohamed Munir, Whitlock Richard P
Abstract excerpt
Variability in vitamin K antagonist (VKA) dosing is partially explained by genetic polymorphisms. We performed a meta-analysis to determine whether genotype-guided VKA dosing algorithms decrease a composite of death, thromboembolic events and major bleeding (primary outcome) and improve time in therapeutic range (TTR). We searched MEDLINE, EMBASE, CENTRAL, trial registries and conference proceedings for...
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