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Article

Meta-Analysis of Genotype-Guided Versus Standard Dosing of Vitamin K Antagonists.

The American journal of cardiology - 1 Apr 2018

Kheiri Babikir, Abdalla Ahmed, Haykal Tarek, Osman Mohammed, Ahmed Sahar, Hassan Mustafa, Bachuwa Ghassan

Abstract excerpt

Vitamin K antagonist (VKA) is a commonly prescribed anticoagulant with a narrow therapeutic window. Genetic polymorphisms account for high VKA dosage variability. Hence, we performed an updated meta-analysis of all randomized clinical trials (RCTs) comparing genotype-guided VKA versus standard dosing algorithms. We conducted a systematic search of electronic databases from inception to October 2017 for all RCTs....

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PMID: 29402419
DOI: 10.1016/j.amjcard.2017.12.023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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