Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of rare coding variants in schizophrenia-associated genes and generalised cognition in the UK Biobank.

Molecular psychiatry - 1 Sept 2026

Fenner Eilidh, Holmans Peter, O'Donovan Michael C, Owen Michael J, Walters James T R, Rees Elliott

Abstract excerpt

Cognitive impairments in schizophrenia are associated with poor outcomes and are largely unimproved by current medications. It remains uncertain to what extent cognitive impairments arise from shared aetiology and biology with schizophrenia, or are a consequence of having the condition. We analysed exome-sequencing data from 76,783 UK Biobank participants without schizophrenia to test for association between...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cognitive Dysfunction
Share to Biological Specimen Banks

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cognition

Share to Exome Sequencing

Share to Schizophrenia

Share to UK Biobank

Share to United Kingdom

Source

Open in PubMed Open full text

Identifiers

PMID: 41963674
DOI: 10.1038/s41380-026-03601-8
PMCID: PMC7619269

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of rare coding variants in schizophrenia-associated genes and generalised cognition in the UK Biobank.PMID 41963674Read ↗

Identification of specific genes involved in schizophrenia aetiology - what difference does it make?Semantic proximity Read ↗

Genome-wide burden of deleterious coding variants increased in schizophrenia.Semantic proximity Read ↗

The contribution of rare variants to risk of schizophrenia in individuals with and without intellectual disability.Semantic proximity Read ↗

Rare schizophrenia risk variant burden is conserved in diverse human populationsSemantic proximity Read ↗

Genetics of schizophrenia.Semantic proximity Read ↗

Rare Copy Number Variants Are Associated With Poorer Cognition in Schizophrenia.Semantic proximity Read ↗

Schizophrenia genomics: genetic complexity and functional insights.Semantic proximity Read ↗

Schizophrenia: a common disease caused by multiple rare alleles.Semantic proximity Read ↗

Ultrarare Coding Variants and Cognitive Function in Schizophrenia-Unraveling the Enduring Mysteries of Neuropsychiatric Genetics.Semantic proximity Read ↗

Shifting the focus toward rare variants in schizophrenia to close the gap from genotype to phenotype.Semantic proximity Read ↗

Genetics of schizophrenia: A consensus paper of the WFSBP Task Force on GeneticsSemantic proximity Read ↗

Clinical features of UK Biobank subjects carrying protein-truncating variants in genes implicated in schizophrenia pathogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.