Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Maternal High-Fat Diet Causes a Sex-Dependent Increase in AGTR2 Expression and Cardiac Dysfunction in Adult Male Rat Offspring.

Biology of reproduction - 1 Aug 2015

Xue Qin, Chen Pinxian, Li Xiongxiong, Zhang Guiping, Patterson Andrew J, Luo Jiandong

Abstract excerpt

Maternal high-fat diet (HFD) is associated with cardiovascular disease later in life. This study tested the hypothesis that maternal HFD causes programming of increased cardiac angiotensin II receptor type 2 (AGTR2) expression, resulting in heightened cardiac susceptibility to ischemic injury in male offspring in a sex-dependent manner. Pregnant rats were divided between control and HFD (HFD-fed during gestation)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Angiotensin II
Share to Angiotensin II Type 1 Receptor Blockers

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cardiomegaly

Share to Fetal Development

Share to Heart Diseases

Share to Myocardial Ischemia

Share to Myocardial Reperfusion Injury

Share to Receptor, Angiotensin, Type 2

Source

Identifiers

PMID: 26157067
DOI: 10.1095/biolreprod.115.129916

Genes

AGTR2
AGTR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Maternal High-Fat Diet Causes a Sex-Dependent Increase in AGTR2 Expression and Cardiac Dysfunction in Adult Male Rat Offspring.PMID 26157067Read ↗

A High Fat Diet During Pregnancy and Lactation Induces Cardiac and Renal Abnormalities in GLUT4 +/- Male Mice.Semantic proximity Read ↗

Sex-Dependent Epigenomic and Transcriptomic Reprogramming Links Maternal Obesity to Cardiac Remodeling in Adult OffspringSemantic proximity Read ↗

The programming of cardiac hypertrophy in the offspring by maternal obesity is associated with hyperinsulinemia, AKT, ERK, and mTOR activation.Semantic proximity Read ↗

Role of Maternal Obesity in Offspring Cardiovascular Development and Congenital Heart DefectsSemantic proximity Read ↗

The Association between High Fat Diet around Gestation and Metabolic Syndrome-related Phenotypes in Rats: A Systematic Review and Meta-Analysis.Semantic proximity Read ↗

Sex-specific programming of hypertension in offspring of late-gestation diabetic rats.Semantic proximity Read ↗

Parental obesity predisposes offspring to kidney dysfunction and increased susceptibility to ischemia-reperfusion injury in a sex-dependent mannerSemantic proximity Read ↗

Maternal obesity causes fetal cardiac hypertrophy and alters adult offspring myocardial metabolism in miceSemantic proximity Read ↗

Transgenerational impact of aberrant inflammation in rat pregnancySemantic proximity Read ↗

Glucocorticoid receptor epigenetic activity in the heartSemantic proximity Read ↗

Long term effects of fetal undernutrition on rat heart. Role of hypertension and oxidative stressSemantic proximity Read ↗

Identification and comparative analyses of myocardial miRNAs involved in the fetal response to maternal obesity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.