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Article

HIV-1 Neutralization: Mechanisms and Relevance to Vaccine Design

1 Nov 2007

Abstract excerpt

Antibody (Ab) mediated neutralization is a crucial means of host resistance to many pathogens and will most likely be required in the development of a vaccine to protect against HIV-1. Here we examine mechanistic aspects of HIV-1 neutralization with attention to recent studies on the stoichiometric, kinetic and thermodynamic parameters involved. Neutralization of HIV-1, as with any microbe, minimally requires an...

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Identifiers

PMID: 18045117
DOI: 10.2174/157016207782418443

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