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Article

PDGFB-based stem cell gene therapy increases bone strength in the mouse

6 Jul 2015

Abstract excerpt

Substantial advances have been made in the past two decades in the management of osteoporosis. However, none of the current medications can eliminate the risk of fracture and rejuvenate the skeleton. To this end, we recently reported that transplantation of hematopoietic stem/progenitor cells (HSCs) or Sca1(+) cells engineered to overexpress FGF2 results in a significant increase in lamellar bone matrix formation...

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PMID: 26150503
DOI: 10.1073/pnas.1501759112

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